1 edition of Polyamines in biology and medicine found in the catalog.
Polyamines in biology and medicine
Includes bibliographical references and index.
|Statement||edited by David R. Morris, Laurence J. Marton.|
|Series||The Biochemistry of disease ;, v. 8|
|Contributions||Morris, David R., 1939-, Marton, Laurence J.|
|LC Classifications||QP801.P638 P63|
|The Physical Object|
|Pagination||xiv, 459 p. :|
|Number of Pages||459|
|LC Control Number||81009757|
TY - CHAP. T1 - Polyamines and Cancer. AU - Damiani, Elisabetta. AU - Wallace, Heather M. PY - Y1 - N2 - This chapter provides an overview of how the polyamine pathway has been exploited as a target for the treatment and prevention of multiple forms Cited by: TY - CHAP. T1 - Biosynthesis of polyamines in eukaryotes, Archaea, and bacteria. AU - Michael, Anthony J. PY - /1/1. Y1 - /1/1. N2 - As with all metabolic pathways, not only has polyamine biosynthesis been subject to divergent and convergent evolution and horizontal gene transfer, but many pathogenic and commensal organisms have abandoned the task altogether and instead obtain Cited by: 4.
More than , women are diagnosed yearly with breast cancer in the United States. Despite the significant improvement in survival introduced by both adjuvant hormonal therapy (restricted to estrogen receptor-positive tumors) and chemotherapy, app Author: Andrea Manni. Most textbooks that deal with biochemistry, molecular biology or cell biology either ignore polyamines completely or provide a highly abbreviated and frequently incorrect mention. This is a most-unfortunate lapse because polyamines are ubiquitous cellular components that play critical roles in many aspects of cellular physiology, including cell Cited by: 1.
Histamine, discovered in by the British physiologist Sir Henry H. Dale, has become one of the most important biogenic amines in medicine and biology. In addition to the three well-known functions such as the contraction of smooth muscles, the increase in vascular permeability, and the stimulation of gastric acid secretion, histamine has been known to play various roles in. In plants, polyamines, some of which are presented as a conjugated form with cinnamic acids and proteins, are involved in a variety of physiological processes. In recent years, the study of plant polyamines, such as their biosynthetic and catabolic pathways and the roles they play in cellular processes, has flourished, becoming an exciting.
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The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is s: 1.
In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study.
The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine Author: Anthony E. Pegg. The first comprehensive book focusing on synthesis and applications of macrocyclic polyamines and their derivatives Macrocyclic polyamines are a class of widely used important compounds.
This is the first book that systematically summarizes the synthesis and applications of macrocyclic polyamines and their analogues, including the properties and synthetic methods of macrocyclic polyamines. This volume provides readers with a collection of the latest protocols used by researchers to study polyamines (PA).
The chapters in this book cover various topics, such as quantification of different polyamines and conjugates, subcellular localization studies, transport, DNA methylation, ODC regulation, genetic and phenotyping analyses, genome-wide association mapping, polyamine applications.
In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine.
Abstract. Although receiving little attention in biochemical and physiological textbooks, the polyamines have a long history and have accumulated a considerable Cited by: Polyamines T A Smith Annual Review of Plant Physiology CROSS-LINKING IN COLLAGEN AND ELASTIN David R.
Eyre, Mercedes A. Paz, and Paul M. Gallop Annual Review of Biochemistry 1,4-Diaminobutane (Putrescine), Spermidine, and Spermine C W Tabor, and and H Tabor. Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions.
An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions.
Over the last decade, considerable progress has been made in und. Several chapters are devoted to the role of polyamines in various aspects of plant biology, with a special emphasis on their participation in the response of plants to extreme environments.
Special attention is given to the use of inhibitors of polyamine biosynthesis as potential antitumor and antiproliferative agents. Biochemistry and Physiology of Polyamines in Plants provides a comprehensive introduction to commonly used methods in polyamine research and the problems unique to plant studies.
Topics discussed include polyamine metabolism in plants, the functions of polyamines in plant growth and development, an. Polyamines in Fungi: Their Distribution, Metabolism, and Role in Cell Differentiation and Morphogenesis provides a complete overview of its topic.
It is the first and only book to describe and analyze the roles of polyamines in fungi and compare them with the roles of polyamines in higher eukaryotes.
Get this from a library. Progress in polyamine research: novel biochemical, pharmacological, and clinical aspects. [Vincenzo Zappia; Anthony E Pegg;] -- Some contributors detail the enzymology and molecular biology of orinthine decarboxylase, AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to.
Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the.
Free Radical Biology and Medicine also commissions themed Special Issues aimed at highlighting recent advances in both basic and clinical fields, with a particular focus on mechanisms underlying altered metabolism and redox signaling.
Polyamine biosynthesis. Polyamines are small, naturally occurring, polycationic alkylamines that are essential for normal cell growth and development in eukaryotes (Refs 1, 2).Both their charge distribution and flexibility allow polyamines to bind to various anionic macromolecules including DNA, RNA, proteins, and acidic phospholipids (Refs 3, 4).The vital importance of polyamines for normal Cited by: Polyamine Protocols is the only compilation of methods currently available for use in studies involving polyamines.
The collection offers both novice and experienced researchers across many fields-including cell and molecular biology, pharmacology, oncology, physiology, laboratory medicine, and clinical pathology-all the tools needed to.
Polyamines are small organic cations that are essential for normal cell growth and development in eukaryotes. Under normal physiological conditions, intracellular polyamine concentrations are tightly regulated through a dynamic network of biosynthetic and catabolic enzymes, and a poorly characterised transport by: Igarashi K, Mitsui K, Kubota M, Shirakuma M, Ohnishi R, Hirose S.
Effect of polyamines on synthesis and degradation of guanosine 5'-diphosphate 3'-diphosphate. Biochim Biophys Acta. Feb 22; (3)– [Google Scholar] Jänne J, Pösö H, Raina A. Polyamines in rapid growth and cancer. Biochim Biophys by: Polyamines (PAs) are essential across all kingdoms of life.
• PAs are tightly regulated by a series of specific and uncommon mechanisms. • PAs are regularly identified in “omic” studies as being associated with stress, aging and disease such as cancer.
• A unifying property of Cited by:. Uncommon Polyamines in Plants and Other Organisms (Gregory C. Phillips and Glenn D. Kuehn). Molecular Analyses of Polyamine Synthesis in Higher Plants (Russell L. Malmberg and Erin Bell).
POLYAMINES IN PLANT GROWTH AND DEVELOPMENT. Polyamines in Cell Division, Fruit Set and Development, and Seed Germination (Marcos Egea-Cortines and Yosef Mizrahi).Editorial Reviews. Reviewer: Alvin Telser, PhD (Northwestern University Feinberg School of Medicine) Description: This is a brief book of detailed procedures on the purification and assay of polyamines — a ubiquitous category of molecules thought to be important in key aspects of cellular growth and division — even though few specific functions have been defined for : $Chapter 13 Roles of Polyamines in Cell Biology NIKOLAUS SEILER Introduction Definitions History General Characteristics Metabolism The Polyamine Metabolic Cycle in the Vertebrate Organism Regulatory and Nonregulatory Enzymes Polyamine Transport Interaction with Macromolecuies Free and Bound Polyamines Interactions With DNA Author: Nikolaus Seiler.